LymeNet Newsletter Volume 5 Issue 01

Volume: 5
Issue: 01
Date: 27-Jan-97

Table of Contents:

I. LYMENET: 10th Annual International Conference on Lyme Disease & other Tick-borne disorders II. LYMENET: New Video Available Detailing LD Issues III. REV CLIN ESP: Evaluation of methods of tick removal in human ixodidiasis IV. SCAND J INFECT DIS: Antibiotics and increased temperature against Borrelia burgdorferi in vitro V. About The LymeNet Newsletter

Newsletter:

*********************************************************************** * The National Lyme Disease Network * * LymeNet Newsletter * ***********************************************************************

IDX# Volume 5 / Number 01 / 24-JAN-97 IDX# INDEX IDX# IDX# I. LYMENET: 10th Annual International Conference on Lyme IDX# Disease & other Tick-borne disorders IDX# II. LYMENET: New Video Available Detailing LD Issues IDX# III. REV CLIN ESP: Evaluation of methods of tick removal in IDX# human ixodidiasis IDX# IV. SCAND J INFECT DIS: Antibiotics and increased temperature IDX# against Borrelia burgdorferi in vitro IDX# V. About The LymeNet Newsletter IDX#

I. LYMENET: 10th Annual International Conference on Lyme Disease & other Tick-borne disorders ------------------------------------------------------------------- Sender: Tom Forschner <[email protected]> Date: January 22, 1997

10th Annual International Conference on Lyme Disease & other Tick-borne disorders

PLACE: National Institutes of Health, Clinical Center Bethesda, Maryland

PROGRAM TOPICS:

Biology and Pathogenesis * Molecular Biology and Genetics * Structure-Function Relationships * Host Immune Response

Prevention * Ecology * Entomology * Animal Models * Vaccines

Patient Management * Clinical Manifestations * Clinical and Laboratory Diagnosis * Early Disseminated Disease Management * Late Disseminated Disease Management * Chronic Disease Management

General Discussion of Hot Topics

Poster Presentations

Public Forum

Workshop on Scientific Manuscript Preparation (writing your scientific data for publication)

PROGRAM COMMITTEE

James Miller, Ph.d. - Conference Chairman Professor, UCLA School of Medicine Benjamin Luft, MD - Conference Co-Chairman Chief of Medicine, SUNY School of Medicine

Basic Science James Miller, Ph.d. - Chairman, UCLA School of Medicine Mario Phillip, Ph.d. - Co-Chairman, Tulane University Steven Barthold, Ph.d. - Yale University David Dorward, Ph.d. - National Institutes of Health Janis Weis, Ph.d. - University of Utah Edward Bolser, Ph.d. - SUNY School of Medicine

Clinical Sessions Benjamin Luft, MD - Chairman, SUNY, School of Medicine Sam Donta, MD - Co-Chairman, Boston Univ. Medical Ctr Patricia Coyle, MD - SUNY School of Medicine Kenneth Liegner, MD - Northern Westchester Hospital Gerold Stanek, MD - Hygiene -Institut der Universitaet Alan Barbour, MD - University of California, Irvine

Poster Session Ron Schell, Ph.d. - Chairman, Univ. of Wisc. Medical School Charles Pavia, Ph.d. - Co-Chairmen, NY Medical College

Public Forum Joseph Burrascano, MD - Internist, Southamptom Hospital Julie Rawlings, MPH - Texas Department of Health

Reception Claude Garon, Ph.d. - National Institutes of Health, RML Ken Liegner, MD - Northern Westchester Hospital

Conference Coordinating Committee Betty Bosler, MPH - SUNY School of Medicine Tom Forschner, MBA, CPA - Executive Director LDF Karen V-Forschner, MBA -Chair LDF

--

CONFERNECE REGISTRATION FORM:

o MD o DO o DVM o PhD o DDS o MPH o RPh o RN o Mr. o Mrs. o Ms. o ____

Last name_________________________________________

First name_________________________________________

Title/position_______________________________________

Institution_________________________________________

Address __________________________________________

__________________________________________

City__________________State________Zip_____________

phone_______________________fax________________________

e-mail______________

o Enroll me in the Workshop (To attend, you must submit a completed scientific manuscript by 4/2/97)

Fees (CME's a separate fee, to be determined) Fees include attendance at scientific sessions, refreshments, book of proceedings, and the reception.

o $200 (by 4/1/97) o $300 (4/ 2-26 /97) o $350 (after 4/26/97) o $150 Poster presenters o $ 35 Reception only (non-registrants)

______ Total Amount Enclosed

Payment Method

o Check enclosed (payable to "Lyme Disease Foundation") o Credit Card Charge o Master Card o Visa o American Express

Card #________________________________________

Expiration date_____/_____

Cardholder's signature:___________________________

Payment must accompany registration and must be in U.S. funds. Mail or fax registration to:

LDF, One Financial Plaza, Hartford, CT 06103 (860) 525-2000 fax (860) 525-8425 EMAIL [email protected]

Written notice of cancellation must be received by the LDF no later than 4/1/97.

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II. LYMENET: New Video Available Detailing LD Issues ------------------------------------------------------ Sender: Stephen Zimmer <[email protected]> Fax: (606)-257-8940 Date: December 11, 1996

Lexington, KY -- The issues involving Lyme Disease, one of the fastest growing and most complicated diseases in the country, are exposed in a new hour long video sponsored by the Lyme Awareness Fund and produced by Diatheke Eirene, LTD. The video, whose proceeds go to fund Lyme Disease research, is an in-depth look at a disease that is well- publicized in the northeastern parts of the United States.

Lyme Disease, primarily conveyed through the bite of a tick, is now diagnosed throughout the continental United States and is becoming an increasing concern for people (and their pets), not just those who spend a significant amount of time in nature settings. Anywhere that a tick can go, from the backyard of a house to a ride on the back of the family's cat, the disease can follow.

With expensive treatments and a known difficulty of diagnosis, as its symptoms simulate other diseases, Lyme Disease is also becoming a point of contention between insurance groups and patient advocacy groups. "Time For Truth" looks into a number of these stories through the eyes of the people affected directly by the conflicts.

The video also features expert insights from researchers, clinical physicians, and psychiatrists, as well as from a professional patient advocate. The video also features a guest appearance by Denise Lang, whose book Coping with Lyme Disease is the biggest selling book on the topic of Lyme Disease. Popular singer Gloria Estefan contributed to the video through her hit song, "Always Tomorrow".

As infected ticks continue to increase in number and range, awareness of Lyme Disease is quickly becoming a vital necessity. Precautions can be taken by those who spend a significant amount of time in nature, a group that is slightly more at risk of exposure, and treatments are available and generally effective if the disease is diagnosed in its early stages.

Knowledge can make a difference, from possible infection to treatment, and "Time For Truth" has been produced to assist in that educational process.

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III. REV CLIN ESP: Evaluation of methods of tick removal in human ixodidiasis ------------------------------------------------------------------ AUTHORS: Oteo JA, Martinez de Artola V, Gomez-Cadinanos R, Casas JM Blanco JR, Rosel L ORGANIZATION: Servicio de Medicina Interna, Hospital de La Rioja, Logrono. REFERENCE: Rev Clin Esp 1996 Sep;196(9):584-7 URL: http://search.lymenet.org/Abstracts/97091472.htm ABSTRACT:

BACKGROUND: There are two questions regarding tick transmitted diseases (Ixodidae) not sufficiently elucidated: How to remove the arthropod? and: should antibiotic prophylaxis be administered after the bite? SUBJECTS AND METHODS: From June 1st, 1991, to December, 31, 1992, all patients who were attended at La Rioja Hospital relating immediate bite or tick bite within the 48 hours before were prospectively studied. In all those patients an epidemiological inquiry was obtained, which included, apart from personal data and risk factors for tick bites, how arthropods had been removed, health exam and blood drawn for serological study for Borrelia burgdorferi and Rickettsia conorii. The protocol was repeated at one, two, four and six months after the bite. The removal method used at the Hospital was by pulling with fine tweezers and later disinfection with iodine povidone. RESULTS: Out of a total of 52 individuals who complied with the established criteria, only 41 ended the follow-up. A 63.4 percent of
patients experienced some type of complication, including 3 cases of LB (erythema migrans). With regard to the type of removal method and the development of complications, only three patients who had ticks pulled with tweezers experienced complications compared with 23 patients who used other methods (p = 0.0058). With regard to specific complications (LB and/or spotted fever) and/or development of B. burgdorferi or R. conorii infection significant differences were also observed when tweezers were used for removal of ticks compared with other tick removal methods (p < 0.05). CONCLUSION: The removal of ticks with tweezers significantly protects from the development of complications and infection by tick-borne microorganisms. Antibiotic prophylaxis is recommended when the removal of the arthropod is carried out by using a method other than the recommended one.

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IV. SCAND J INFECT DIS: Antibiotics and increased temperature against Borrelia burgdorferi in vitro --------------------------------------------------------------- AUTHORS: Reisinger E, Wendelin I, Gasser R, Halwachs G Wilders-Truschnig M, Krejs G ORGANIZATION: Department of Medicine, Karl Franzens University, Graz, Austria. REFERENCE: Scand J Infect Dis 1996;28(2):155-7 URL: http://search.lymenet.org/Abstracts/96384594.htm ABSTRACT:

In 1917, spirochaetal neurosyphilis was treated successfully with malariotherapy in combination with salvarsan or bismuth. Malariotherapy for spirochaetal Lyme disease has been discussed, but the mechanism of an antispirochaetal effect remains unclear. We cultured Borrelia burgdorferi at different temperatures, alone and in combination with antibiotics. Our data demonstrate that growth of the strains PKo and ATCC 35210 (B31) was impaired at temperatures of 37 degrees C and inhibited at 39 degrees C and 40 degrees C, respectively. Strain ATCC 35211, however, grew well up to 39 degrees C but did not multiply at 40 degrees C. A bactericidal effect was seen at 41 degrees C for the strains B31 and PKo and at 42 degrees C for all strains. The susceptibility of all strains to penicillin and ceftriaxone was increased up to 16-fold by an elevation of temperature from 36 degrees C to 39 degrees C. These in vitro data suggest that elevated body temperature may be beneficial during antimicrobial treatment of Lyme disease. This may be
particularly important in tissues where high concentrations of antibiotics are difficult to achieve.

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V. ABOUT THE LYMENET NEWSLETTER ----------------------------------- For the most current information on LymeNet subscriptions, contributions, and other sources of information on Lyme disease, please refer to the LymeNet Home Page at: http://www.lymenet.org ----------------------------------------------------------------------- To unsubscribe from the LymeNet newsletter, send a message to: [email protected] On the first line of the message, write: unsub lymenet-l ----------------------------------------------------------------------- LymeNet - The Internet Lyme Disease Information Source ----------------------------------------------------------------------- Editor-in-Chief: Marc C. Gabriel <[email protected]> FAX (for contributions ONLY): 908-789-0028 Contributing Editors: Carl Brenner <[email protected]> John Setel O'Donnell <[email protected]> Frank Demarest <[email protected]> Advisors: Carol-Jane Stolow, Director <[email protected]>
William S. Stolow, President <[email protected]> The Lyme Disease Network of New Jersey ----------------------------------------------------------------------- WHEN COMMENTS ARE PRESENTED WITH AN ATTRIBUTION, THEY DO NOT NECESSARILY REPRESENT THE OPINIONS/ANALYSES OF THE EDITORS. ----------------------------------------------------------------------- THIS NEWSLETTER MAY BE REPRODUCED AND/OR POSTED ON BULLETIN BOARDS FREELY AS LONG AS IT IS NOT MODIFIED OR ABRIDGED IN ANY WAY. ----------------------------------------------------------------------- SEND ALL BUG REPORTS TO [email protected] -----------------------------------------------------------------------